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In this study, hydroxyapatite (HA)-sodium potassium niobate (NKN) composites with varying concentrations of NKN (10, 20, and 30 wt %) were optimally developed at 1075 °C for 2 h. Detailed microstructural analyses have been performed by means of scanning and transmission electron microscopy. The maximum fracture toughness, hardness, and compressive and flexural strengths were obtained to be ∼209, ∼93, ∼112, and ∼88%, respectively, for the HA-30 wt % NKN composite compared to monolithic HA. The antibacterial tests revealed the significant reduction in bacterial viability on poled (@ 20 kV for 30 min at 500 °C) HA-NKN composite samples while cultured with Staphylococcus aureus and Escherichia coli bacteria. The cytocompatibility tests revealed the significantly enhanced MG63 cell proliferation for electrical stimulation-treated negatively charged HA and H30N composite samples.

Citation

Alok Singh Verma, Ankur Sharma, Ajay Kumar, Amartya Mukhopadhyay, Devendra Kumar, Ashutosh Kumar Dubey. Multifunctional Response of Piezoelectric Sodium Potassium Niobate (NKN)-Toughened Hydroxyapatite-Based Biocomposites. ACS applied bio materials. 2020 Aug 17;3(8):5287-5299


PMID: 35021703

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