Immunomodulatory effects of mesenchymal stem cells in peripheral nerve injury.

Xiangling Li, Yanjun Guan, Chaochao Li, Tieyuan Zhang, Fanqi Meng, Jian Zhang, Junyang Li, Shengfeng Chen, Qi Wang, Yi Wang, Jiang Peng, Jinshu Tang

Stem cell research & therapy 2022 Jan 15

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Various immune cells and cytokines are present in the aftermath of peripheral nerve injuries (PNI), and coordination of the local inflammatory response is of great significance for the recovery of PNI. Mesenchymal stem cells (MSCs) exhibit immunosuppressive and anti-inflammatory abilities which can accelerate tissue regeneration and attenuate inflammation, but the role of MSCs in the regulation of the local inflammatory microenvironment after PNI has not been widely studied. Here, we summarize the known interactions between MSCs, immune cells, and inflammatory cytokines following PNI with a focus on the immunosuppressive role of MSCs. We also discuss the immunomodulatory potential of MSC-derived extracellular vesicles as a new cell-free treatment for PNI. © 2022. The Author(s).

Citation

Xiangling Li, Yanjun Guan, Chaochao Li, Tieyuan Zhang, Fanqi Meng, Jian Zhang, Junyang Li, Shengfeng Chen, Qi Wang, Yi Wang, Jiang Peng, Jinshu Tang. Immunomodulatory effects of mesenchymal stem cells in peripheral nerve injury. Stem cell research & therapy. 2022 Jan 15;13(1):18