Atomically Precise Water-Soluble Graphene Quantum Dot for Cancer Sonodynamic Therapy.

Although water-soluble graphene quantum dots (GQDs) have shown various promising bio-applications due to their intriguing optical and chemical properties, the large heterogeneity in compositions, sizes, and shapes of these GQDs hampers the better understanding of their structure-properties correlation and further uses in terms of large-scale manufacturing practices and safety concerns. It is shown here that a water-soluble atomically-precise GQD (WAGQD-C96 ) is synthesized and exhibits a deep-red emission and excellent sonodynamic sensitization. By decorating sterically hindered water-soluble functional groups, WAGQD-C96 can be monodispersed in water without further aggregation. The deep-red emission of WAGQD-C96 facilitates the tracking of its bio-process, showing a good cell-uptake and long-time retention in tumor tissue. Compared to traditional molecular sonosensitizers, WAGQD-C96 generates superior reactive oxygen species and demonstrates excellent tumor inhibition potency as an anti-cancer sonosensitizer in in vivo studies. A good biosafety of WAGQD-C96 is validated in both in vitro and in vivo assays. © 2022 The Authors. Advanced Science published by Wiley-VCH GmbH.

Citation

Yang-Yang Ju, Xiao-Xiao Shi, Shu-Yu Xu, Xiao-Hui Ma, Rong-Jing Wei, Hao Hou, Cheng-Chao Chu, Di Sun, Gang Liu, Yuan-Zhi Tan. Atomically Precise Water-Soluble Graphene Quantum Dot for Cancer Sonodynamic Therapy. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2022 Jul;9(19):e2105034

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PMID: 35038238

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