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The reasons underpinning the large differences in the prevalence of resistance to macrolides in Streptococcus pneumoniae are imperfectly understood. We assessed if the volume of macrolides used in food-animals could play a role. Logistic regression was used to assess if the country-level prevalence of pneumococcal macrolide resistance was associated with country-level macrolide consumption in food animals and humans. In both univariate and multivariate models, macrolide use in food-producing animals was significantly associated with pneumococcal macrolide resistance (coeff. = 339, 95% CI 21 - 658; P = 0.037). In vitro and individual-level studies are required to verify or refute the hypothesis that macrolides used in food animals can promote the spread of macrolide resistance in humans. Copyright © 2022 The Author(s). Published by Elsevier Ltd.. All rights reserved.


Chris Kenyon. Positive association between the use of macrolides in food-producing animals and pneumococcal macrolide resistance: a global ecological analysis. International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases. 2022 Mar;116:344-347

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PMID: 35038599

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