Pinellic Acid Isolated from Quercetin-rich Onions has a Peroxisome Proliferator-Activated Receptor-Alpha/Gamma (PPAR-α/γ) Transactivation Activity.

Mikio Doi, Naoki Morita, Tsugumi Okuzawa, Satoru Ohgiya, Daisaku Okamoto, Kenichi Sato, Yukiya Ito, Hideyuki Matsuura, Yasuyuki Hashidoko

Planta medica 2022 May

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Quercetin, a flavonol, is a functional compound that is abundant in onions and is known to have antioxidant and anti-inflammatory effects. Quercetin and its glucoside are known to function as peroxisome proliferator-activated receptor (PPAR) ligands and showed high PPAR-α transactivation activity but little PPAR-γ transactivation activity in some reports. In this study, we demonstrated that an aqueous extract of a quercetin-rich onion cultivar increased transactivation activities not only of PPAR-α but also of PPAR-γ. We isolated (9S,12S,13S)-(10E)-9,12,13-trihydroxyoctadec-10-enoic acid (pinellic acid) obtained from the aqueous extract using PPAR-γ transactivation as an index. Furthermore, it was revealed that pinellic acid could transactivate PPAR-α. Our findings are the first report mentioned showing that trihydroxyoctadec-10-enoic acids showed PPAR-α/γ transactivation activities. Thieme. All rights reserved.

Citation

Mikio Doi, Naoki Morita, Tsugumi Okuzawa, Satoru Ohgiya, Daisaku Okamoto, Kenichi Sato, Yukiya Ito, Hideyuki Matsuura, Yasuyuki Hashidoko. Pinellic Acid Isolated from Quercetin-rich Onions has a Peroxisome Proliferator-Activated Receptor-Alpha/Gamma (PPAR-α/γ) Transactivation Activity. Planta medica. 2022 May;88(6):440-446