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Rosettes: a shield for Plasmodium falciparum against artemisinins?

Stephen J Rogerson

Trends in parasitology 2022 Mar


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  • artemisinins (3)
  • parasites (1)
  • plasmodium falciparum (3)
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    Relative resistance of Plasmodium falciparum parasites to artesunate (AS) has been ascribed to mutations in the Kelch 13 gene. Lee et al. describe another potential contributor to resistance: the induction of increased rosetting by trophozoite-infected erythrocytes following short exposures to AS. Dissecting this phenomenon may lead to new insights into AS resistance. Copyright © 2021 Elsevier Ltd. All rights reserved.

    Citation

    Stephen J Rogerson. Rosettes: a shield for Plasmodium falciparum against artemisinins? Trends in parasitology. 2022 Mar;38(3):193-194

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    PMID: 35039237

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