Stabilization of Antitumor Agent Busulfan through Encapsulation within a Water-Soluble Pillar[5]arene.

The complexation of the antitumor agent busulfan by negatively charged carboxylatopillar[5]arene in water is reported. The encapsulation within carboxylatopillar[5]arene reduces the hydrolytic degradation of busulfan from 90.7% to 25.2% after 24 days and accordingly enhances its stability by providing a hydrophobic shelter for busulfan in water. Moreover, the complexation results in 12 times improvement of water solubility for busulfan. Our result provides a supramolecular approach for stabilizing the anticancer agent busulfan. © 2022 Wiley-VCH GmbH.

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Hui-Feng Xue, Yu Xi Huang, Ming Dong, Zhi-Yuan Zhang, Chunju Li. Stabilization of Antitumor Agent Busulfan through Encapsulation within a Water-Soluble Pillar[5]arene. Chemistry, an Asian journal. 2022 Mar 14;17(6):e202101332

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PMID: 35040585

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