New insight into old and new antimicrobial molecules targeting quorum sensing for MRSA wound infection.

MRSA represents one of the largest problems in wound healing as a result of its increasing incidence and the complex therapeutic approach required to treat it. The need for new solutions to overcome antibiotic resistance led to the development of antimicrobial molecules that are effective at blocking quorum sensing. This special report provides an up-to-date review, based on the latest evidence in the literature, of old and new molecules that can positively influence the process of wound healing via their action on MRSA quorum sensing. Quorum sensing-inhibiting molecules, applied topically or injected in situ, have excellent potential to improve both MRSA eradication and quality of wound healing, especially when combined with conventional systemic MRSA therapy. Further human studies are needed to evaluate the efficacy of these molecules.

Citation

Oriana Simonetti, Giulio Rizzetto, Oscar Cirioni, Elisa Molinelli, Gianluca Morroni, Andrea Giacometti, Annamaria Offidani. New insight into old and new antimicrobial molecules targeting quorum sensing for MRSA wound infection. Future microbiology. 2022 Feb;17:177-183

Mesh Tags

Substances

PMID: 35040689

search → result