Chemoproteomic profiling reveals celastrol as a potential modulator of cholesterol signaling.

Yiyun Geng, Jingyuan Xu, Weichao Li, Qing Li, Chenjinxin Shen, Zhangshuang Deng, Yiqing Zhou

Chemical communications (Cambridge, England) 2022 Feb 08

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We report a quantitative chemoproteomic approach that utilizes a clickable photoreactive probe for global profiling of celastrol targets, which may significantly improve the current understanding of celastrol's mode of action.

Citation

Yiyun Geng, Jingyuan Xu, Weichao Li, Qing Li, Chenjinxin Shen, Zhangshuang Deng, Yiqing Zhou. Chemoproteomic profiling reveals celastrol as a potential modulator of cholesterol signaling. Chemical communications (Cambridge, England). 2022 Feb 08;58(12):1914-1917