Self-assembled nanoparticles based on supramolecular-organic frameworks and temoporfin for an enhanced photodynamic therapy in vitro and in vivo.

Water-soluble three-dimensional supramolecular-organic frameworks (SOFs) and temoporfin (mTHPC) are discovered to form uniform self-assembled nanoparticles. These nanoparticles demonstrate an improved 1O2 generation efficiency due to the reduced aggregation-caused quenching effect. SOFs and self-assembled nanoparticles are biocompatible. Self-assembled nanoparticles display an improved photo cytotoxicity toward four types of human cancer cells. The tumor model in mice shows that self-assembled nanoparticles could efficiently suppress tumor growth in vivo.

Citation

Zi-Yue Xu, Weipeng Mao, Zizhen Zhao, Ze-Kun Wang, Yue-Yang Liu, Yan Wu, Hui Wang, Dan-Wei Zhang, Zhan-Ting Li, Da Ma. Self-assembled nanoparticles based on supramolecular-organic frameworks and temoporfin for an enhanced photodynamic therapy in vitro and in vivo. Journal of materials chemistry. B. 2022 Feb 09;10(6):899-908

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PMID: 35043828

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