Synthetic Biology-Based Discovery of Diterpenoid Pyrones from the Genome of Eupenicillium shearii.

Yohei Morishita, Kento Tsukada, Kazuma Murakami, Kazuhiro Irie, Teigo Asai

Journal of natural products 2022 Feb 25

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Diterpenoid pyrones are a type of mainly fungal meroterpenoid metabolite consisting of a diterpene connected to a pyrone, some of which show potent bioactivity. Through genome mining and heterologous expression, nine new diterpenoid pyrones, shearones A-I (1-9), were discovered from the fungus Eupenicillium shearii IFM 42152, and their biosynthetic enzyme activities were revealed. Some of these heterologously biosynthesized diterpenoid pyrones exhibited moderate antiaggregative ability against amyloid β42 in vitro.

Citation

Yohei Morishita, Kento Tsukada, Kazuma Murakami, Kazuhiro Irie, Teigo Asai. Synthetic Biology-Based Discovery of Diterpenoid Pyrones from the Genome of Eupenicillium shearii. Journal of natural products. 2022 Feb 25;85(2):384-390