The cross-talk between tumor-associated macrophages and tumor endothelium: Recent advances in macrophage-based cancer immunotherapy.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Feb

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Tumor-associated macrophages (TAMs) are among the abundant cell populations of the tumor microenvironment (TME), which have pivotal roles in tumor development, chemoresistance, immune evasion, and metastasis. Growing evidence indicates that TAMs and the cross-talk between TAMs and tumoral endothelial cells can substantially contribute to tumor angiogenesis, which is considered a vital process for cancer development. Besides, tumoral endothelial cells can regulate the leukocyte infiltration to the TME in solid cancers and contribute to immune evasion. Therefore, targeting the immunosuppressive TAMs and the cross-talk between them can be a promising strategy for improving anti-tumoral immune responses. This review aims to summarize the biology of TAMs, their recently identified roles in tumor development/angiogenesis, and recent advances in macrophage-based cancer immunotherapy approaches for treating cancers. Copyright © 2021. Published by Elsevier Masson SAS.

Citation

Ali Baradaran, Zahra Asadzadeh, Nima Hemmat, Amir Baghbanzadeh, Mahdi Abdoli Shadbad, Neda Khosravi, Afshin Derakhshani, Hajar Alemohammad, Mina Afrashteh Nour, Hossein Safarpour, Nicola Silvestris, Oronzo Brunetti, Behzad Baradaran. The cross-talk between tumor-associated macrophages and tumor endothelium: Recent advances in macrophage-based cancer immunotherapy. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 Feb;146:112588