Exosomes in cardiovascular diseases: a blessing or a sin for the mankind.

Shruti Sharma, Ujjawal Sharma

Molecular and cellular biochemistry 2022 Mar

filter terms:

Cardiovascular diseases (CVDs) comprises disorders of blood vessels and heart. Multiple cells in the heart suggests that hetero-cellular communication, which is an important aspect in heart functioning and there is a need to elucidate the way in which this inter-cellular communication occurs. Now a days, exosomal research has gained much attention. Exosomes, nano-shuttles, are EVs with diameters ranging from 40 to 160 nm (average 100 nm), secreted by body cells. These vesicles act as cell-to-cell communicators and are carriers of important biomolecules such as RNAs, miRNAs, Proteins and lipids. Exosomes can change the gene expression of the recipient cells, thereby, changes the cellular characteristics. Exosomes have known to play an essential role in protection as well as progression of various cardiovascular diseases. In the present review, role of exosomes in various CVDs have been discussed. © 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

Citation

Shruti Sharma, Ujjawal Sharma. Exosomes in cardiovascular diseases: a blessing or a sin for the mankind. Molecular and cellular biochemistry. 2022 Mar;477(3):833-847