High-fat/high-carbohydrate-diet short- and middle-term effects on gerbil adrenal zona fasciculata histology.

Zineb Bellahreche, Nesrine Semiane, Aicha Mallek, Yasmina Dahmani

Tissue & cell 2022 Apr

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The adrenals synthesize many hormones involved in the regulation and maintenance of homeostasis. To understand the pathophysiological changes during the development of obesity, a histological study of the adrenal was performed in gerbils receiving a high-fat/high-carbohydrate-diet (HFC) for 8 or 12 weeks. Compared to the controls, the HFC diet increased body weight. Our results reveal significant weight and structural changes in the HFC group's adrenal glands (confirmed by gray level co-occurrence matrix texture and fractal analysis), disorganization of zona fasciculata (8 weeks) and hyperplasia and peri-capillary fibrosis (12 weeks). In conclusion, these results show that an HFC induces time-dependent structural lesions of the adrenals in gerbils, which could be a sign of chronic adaptation of these glands. Copyright © 2022 Elsevier Ltd. All rights reserved.

Citation

Zineb Bellahreche, Nesrine Semiane, Aicha Mallek, Yasmina Dahmani. High-fat/high-carbohydrate-diet short- and middle-term effects on gerbil adrenal zona fasciculata histology. Tissue & cell. 2022 Apr;75:101729