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    We disclose a mild and practical catalyst-free transformation for the expeditious construction of biuret-guanidine derivatives using aromatic isocyanates. This synthetic transformation is featured with mild reaction conditions and high efficiency.


    Zhen Yang, Ting-Ting Cao, Yun-Fang Sun, Dao-Shun Wu, Yue Xu, Shi-Hai Yang, Shu-Qin Wang, Lei Wang. Expeditious assembly of biuret-guanidine derivatives via the catalyst-free transformation. Journal of Asian natural products research. 2022 Mar;24(3):259-267

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    PMID: 35068269

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