The prospects of DNA damage repair variants guiding platinum compounds in the treatment of triple negative breast cancer].

X Wang, J Yue, Y K Kang, S L Gao, P Yuan

Zhonghua zhong liu za zhi [Chinese journal of oncology] 2022 Jan 23

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Triple negative breast cancer (TNBC) is prone to recurrence and metastasis, which is the subtype of poorest prognosis. Chemotherapy is the main treatment, although there is lack of effective adjuvant chemotherapy regimens. The unsatisfactory efficacy of chemotherapy has been a bottleneck in improving the outcome of TNBC. Platinum compounds act directly on DNA to kill tumor cells, and they have a stronger killing effect on tumor cells carrying DNA damage repair (DDR) defects, which is an important entry point to improve the efficacy of TNBC. Biomarkers for predicting the efficacy of platinum drugs in TNBC treatment have always been a hot topic. The DDR pathway contains a large number of related genes, and recent studies have shown that deficiencies in the DDR pathway may be associated with the efficacy of platinum drugs, which is expected to be a biomarker for predicting the efficacy of platinum drugs in breast cancer treatment.

Citation

X Wang, J Yue, Y K Kang, S L Gao, P Yuan. The prospects of DNA damage repair variants guiding platinum compounds in the treatment of triple negative breast cancer]. Zhonghua zhong liu za zhi [Chinese journal of oncology]. 2022 Jan 23;44(1):68-72