Trauma and resistance to antipsychotic treatment in schizophrenia: A narrative review.

Hélène Verdoux, Aude Sibert, Clélia Quiles

Psychiatry research 2022 Mar

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This review explored whether trauma exposure is associated with poorer response to antipsychotic treatment in schizophrenia patients. A systematic search identified eight studies, of which five reported an association between trauma and non-remission of psychotic symptoms (n = 4) or treatment-resistant schizophrenia (TRS, n = 1). Although evidence supporting the link between trauma and resistance to antipsychotic treatment is scarce, trauma history should be systematically investigated in all persons with TRS, as there is a growing body of evidence showing that schizophrenia patients benefit from therapies for post-traumatic symptoms. Copyright © 2022. Published by Elsevier B.V.

Citation

Hélène Verdoux, Aude Sibert, Clélia Quiles. Trauma and resistance to antipsychotic treatment in schizophrenia: A narrative review. Psychiatry research. 2022 Mar;309:114392