Hypoxia-Responsive Platinum Supernanoparticles for Urinary Microfluidic Monitoring of Tumors.

Qin Xu, Yongchun Pan, Xinli Liu, Yanfeng Gao, Xiaowei Luan, Fei Zeng, Dongtao Zhou, Wenxiu Long, Yuzhen Wang, Yujun Song

Angewandte Chemie (International ed. in English) 2022 Mar 28

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Cancer has become a leading cause of morbidity and mortality, and there is an increasing need for versatile tools to enable sensitive, simple and early cancer monitoring. Here, we report platinum supernanoparticles as an exogenous nanosensor which can dissociate into ultrasmall platinum nanoclusters (PtNCs) under tumor-specific hypoxia conditions. The resulting PtNCs can be filtered through the kidney as urinary reporters to be quantified by a companion volumetric bar-chart chip (V-Chip) for point-of-care analysis. The V-Chip signals of triple-negative breast cancer and its lung metastasis mouse model showed a significant increase compared to healthy mice. Our nanosensor can also noninvasively monitor the course of treatment, which is significant for screening tumor recurrence and individualized evaluation of pharmacological and follow-up efficacy. Importantly, this strategy could be adapted for various diseases to form a common diagnostic platform by changing responsive linkers. © 2022 Wiley-VCH GmbH.

Citation

Qin Xu, Yongchun Pan, Xinli Liu, Yanfeng Gao, Xiaowei Luan, Fei Zeng, Dongtao Zhou, Wenxiu Long, Yuzhen Wang, Yujun Song. Hypoxia-Responsive Platinum Supernanoparticles for Urinary Microfluidic Monitoring of Tumors. Angewandte Chemie (International ed. in English). 2022 Mar 28;61(14):e202114239