Strain specific behavioral and physiological responses to constant light in male CBA/J and CBA/CaJ mice.

Being visually impaired increases the likelihood of sleep disorders and altered behavior. This study investigated physiological and behavioral differences in two similar mice substrains when exposed to constant light (LL) - CBA/J with retinal degeneration and CBA/CaJ mice (no retinal degeneration). Male CBA/J and CBA/CaJ mice were placed into a 12:12 light:dark cycle or constant light (LL). Open field behavior, metabolic markers, and home-cage circadian activity were observed. CBA/CaJ mice have greater circadian period lengthening, increased weight gain, reduced glucose, and increased novelty-induced locomotor activity in LL, compared to CBA/J mice. LL reduced thyroid hormone and insulin in both substrains. While several baseline substrain differences were elucidated, CBA/CaJ mice were more effected by the exposure to LL than the blind CBA/J mice. These results illustrate that LL causes alterations in physiology and behavior and that circadian photoreceptivity might contribute to these effects.

Citation

Hannah V Deane, Holly A Concepcion, Avery E Gatewood, Janessa Quintana, Joseph A Seggio. Strain specific behavioral and physiological responses to constant light in male CBA/J and CBA/CaJ mice. Sleep science (Sao Paulo, Brazil). 2021 Apr-Jun;14(Spec 2):167-173

PMID: 35082987

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