Study on the Mechanism of Fentanyl in Pain Treatment Based on Network Pharmacology.

Shuqin Zhou, Juan Bi, Wei Zhao, Jian Zhao, Honghong Wan, Sheng Wang

Journal of healthcare engineering 2022

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This is a study that is based on network pharmacology, focusing on the pharmacological mechanism of fentanyl in easing pain. Through PPI, GO, and KEGG network pharmacology, the potential pharmacological mechanism of fentanyl was studied. This study compared and analyzed the overlap between the target genes of the active ingredient of fentanyl and the pain treatment target genes. After constructing PPI based on fentanyl, the GO and KEDD pathways were analyzed for enrichment. On the basis of overlapping genes, we constructed the PPI, GO, and KEGG, and analysis showed that the mechanism was likely to be related to some biological process. This study preliminarily identified the important proteins and metabolic pathways related to fentanyl in pain treatment and expected to provide new evidence and research ideas for the use of fentanyl, enhancing effects and alleviating adverse drug reactions. Copyright © 2022 Shuqin Zhou et al.

Citation

Shuqin Zhou, Juan Bi, Wei Zhao, Jian Zhao, Honghong Wan, Sheng Wang. Study on the Mechanism of Fentanyl in Pain Treatment Based on Network Pharmacology. Journal of healthcare engineering. 2022;2022:4139200