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In this paper, we investigate the presence of latrunculin A in the outer rim of a nudibranch Chromodoris kuiteri and show that by combining ultrathin cryosection methods with MALDI MSI we can achieve improved lateral (x and y) resolution and very high resolution in the z dimension by virtue of the ultrathin 200 nm thin cryosections. We also demonstrate that a post ionization laser increases sensitivity. Recent advances in MALDI source design have improved the lateral resolution (x and y) and sensitivity during MSI. Taken together, very high z resolution, from ultrathin sections, and improved lateral (x and y) resolution will allow for subcellular molecular imaging with the potential for subcellular 3D volume reconstruction.


Brett R Hamilton, Weili Chan, Karen L Cheney, Robert K P Sullivan, Matthias Floetenmeyer, Mary J Garson, Roger Wepf. Cryo-ultramicrotomy and Mass Spectrometry Imaging Analysis of Nudibranch Microstructures. Journal of the American Society for Mass Spectrometry. 2022 Mar 02;33(3):592-597

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PMID: 35084175

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