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Currently, the market demand of the non-animal-derived cholesterol is increasing. A novel synthetic route of producing cholesterol was developed through multiple reactions from plant-sourced and commercially available bisnoralcohol (BA). The key reaction conditions, including solvents, reaction temperatures, bases and reducing agents of the route were investigated and optimized. In this straightforward synthetic pathway of cholesterol, most of the reaction steps possess high conversions with average yields of 94%, and the overall yield is up to 74% (5 steps) from the BA. The epicholesterol and were also synthesized. This promising route offers economical and efficient strategies for potential large-scale production of plant-derived cholesterol. Copyright © 2022 Elsevier Inc. All rights reserved.


Xing-Zi Li, Chen-Chen Li, Cheng-Yu Jiang, Zhi-Liang Jing, Xiang-Zhong Gu, Hao-Jie Ni, Wen-Wei Qiu. Synthesis of plant-derived cholesterol from bisnoralcohol. Steroids. 2022 Feb;178:108967

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PMID: 35085676

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