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    Blood homocysteine appears to be increased in Parkinson's disease (PD) and may play a role in the development and progression of this disorder. However, the specific contribution of abnormal homocysteine levels to cortical degeneration in PD remains elusive. To characterize the cortical structural correlates of homocysteine levels in PD. From the COPPADIS cohort, we identified a subset of PD patients and healthy controls (HC) with available homocysteine and imaging data. Surface-based vertex-wise multiple regression analyses were performed to investigate the cortical macrostructural (cortical thinning) and microstructural (increased intracortical diffusivity) correlates of homocysteine levels in this sample. A total of 137 PD patients and 43 HC were included. Homocysteine levels were increased in the PD group (t = -2.2, p = 0.03), correlating in turn with cognitive performance (r = -0.2, p = 0.03). Homocysteine in PD was also associated with frontal cortical thinning and, in a subset of patients with available DTI data, with microstructural damage in frontal and posterior-cortical regions (p < 0.05 Monte-Carlo corrected). Homocysteine in PD appears to be associated with cognitive performance and structural damage in the cerebral cortex. These findings not only reinforce the presence and importance of cortical degeneration in PD, but also suggest that homocysteine plays a role among the multiple pathological processes thought to be involved in its development. Copyright © 2022 Elsevier B.V. All rights reserved.


    Frederic Sampedro, Saul Martínez-Horta, Andrea Horta-Barba, Michel J Grothe, Miguel A Labrador-Espinosa, Silvia Jesús, Astrid Adarmes-Gómez, Fátima Carrillo, Arnau Puig-Davi, Florinda Roldán Lora, Miquel Aguilar Barberá, Pau Pastor, Sonia Escalante Arroyo, Berta Solano Vila, Anna Cots Foraster, Javier Ruiz Martínez, Francisco Carrillo Padilla, Mercedes Pueyo Morlans, Isabel González Aramburu, Jon Infante Ceberio, Jorge Hernández Vara, Oriol de Fábregues-Boixar, Teresa de Deus Fonticoba, Asunción Ávila, Juan Carlos Martínez-Castrillo, Helena Bejr-Kasem, Antonia Campolongo, Berta Pascual-Sedano, COPPADIS Study Group, Pablo Martínez-Martín, Diego Santos-García, Pablo Mir, Jaime Kulisevsky. Increased homocysteine levels correlate with cortical structural damage in Parkinson's disease. Journal of the neurological sciences. 2022 Mar 15;434:120148

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    PMID: 35085959

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