Correlation Engine 2.0
Clear Search sequence regions

Sizes of these terms reflect their relevance to your search.

Neuropathic pain after brachial plexus injury (NPBPI) is a highly disabling clinical condition and is increasingly prevalent due to increased motorcycle accidents. Currently, no randomized controlled trials have evaluated the effectiveness of non-invasive brain stimulation techniques such as repetitive transcranial magnetic stimulation (rTMS) and transcranial direct-current stimulation (tDCS) in patients suffering from NPBPI. In this study, we directly compare the efficacy of 10-Hz rTMS and anodal 2 mA tDCS techniques applied over the motor cortex (5 daily consecutive sessions) in 20 patients with NPBPI, allocated into 2 parallel groups (active or sham). The order of the sessions was randomised for each of these treatment groups according to a crossover design and separated by a 30-day interval. Scores for "continuous" and "paroxysmal" pain (primary outcome) were tabulated after the last stimulation day and 30 days after. Secondary outcomes included the improvement in multidimensional aspects of pain, anxiety state and quality of life from a qualitative and quantitative approach. Active rTMS and tDCS were both superior to sham in reducing continuous (p < 0.001) and paroxysmal (p = 0.002; p = 0.02) pain as well as in multidimensional aspects of pain (p = 0.001; p = 0.002) and anxiety state (p =  < 0.001; p = 0.005). Our results suggest rTMS and tDCS are able to treat NPBPI with little distinction in pain and anxiety state, which may promote the use of tDCS in brachial plexus injury pain management, as it constitutes an easier and more available technique.Clinical Trial Registration:, RBR-5xnjbc - Sep 3, 2018. © 2022. The Author(s).


Erickson Duarte Bonifácio de Assis, Wanessa Kallyne Nascimento Martins, Carolina Dias de Carvalho, Clarice Martins Ferreira, Ruth Gomes, Evelyn Thais de Almeida Rodrigues, Ussânio Mororó Meira, Ledycnarf Januário de Holanda, Ana Raquel Lindquist, Edgard Morya, Cristina Katya Torres Teixeira Mendes, Thaís Castro Gomes de Assis, Eliane Araújo de Oliveira, Suellen Marinho Andrade. Effects of rTMS and tDCS on neuropathic pain after brachial plexus injury: a randomized placebo-controlled pilot study. Scientific reports. 2022 Jan 27;12(1):1440

Expand section icon Mesh Tags

Expand section icon Substances

PMID: 35087138

View Full Text