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    Laser ablation-isotope ratio mass spectrometry (LA-IRMS) allows the mapping analysis of carbon isotope (δ13C) signature in organism samples.Matrix assisted laser desorption ionization time-of-flightimaging mass spectrometry (MALDI-TOF-IMS) enables image of target directly. In this study, the distribution of δ13C and fullerenol nanoparticles in Daphnia magna (D. magna) exposed to different fullerenol solution are mapped using the LA-IRSM and MALDI-TOF-IMS for comparison. We visualize thedistribution of fullerenol nanoparticles mainly in the intestine, also in other parts of the body as well. This is the first time that fullerenol nanoparticles was found outside the intestine of D. magna, which has been confirmed by the two imaging methods individually. Although the both imaging methods are applicable to in-situ visualize the localization and spatial distribution of fullerenol nanoparticles in organisms, MALDI-TOF-IMS is more suitable, in terms of sample preparation and image resolution. The results of our study will also provide a new idea and method for the research of environmental toxicology. Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.

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    Qiuyue Shi, Cheng Fang, Changzhou Yan, Xue-Ling Chang, Xian Zhang, Han Zhang. Visualization of fullerenol nanoparticles distribution in Daphnia magna using Laser Ablation-isotope Ratio Mass (LA-IRMS) and Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry (MALDI-IMS). Ecotoxicology and environmental safety. 2022 Mar 01;232:113226

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    PMID: 35093811

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