Retrospective Cohort Study of the Incidence and Outcomes of Jarisch-Herxheimer Reactions After Treatment of Infectious Syphilis in Late Pregnancy.

Stephen Macumber, Ameeta E Singh, Jennifer Gratrix, Joan L Robinson, Petra Smyczek, Lindsay Rathjen, Cameron Sklar

Sexually transmitted diseases 2022 Oct 01

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Of 39 pregnant women at ≥20 weeks' gestation treated with benzathine penicillin G for infectious syphilis, we identified only 2 mild Jarisch-Herxheimer reactions. There were no immediate fetal sequelae. Data from our study do not support the recommendation for routine admission for the treatment of infectious syphilis in late pregnancy. Copyright © 2022 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Sexually Transmitted Diseases Association.

Citation

Stephen Macumber, Ameeta E Singh, Jennifer Gratrix, Joan L Robinson, Petra Smyczek, Lindsay Rathjen, Cameron Sklar. Retrospective Cohort Study of the Incidence and Outcomes of Jarisch-Herxheimer Reactions After Treatment of Infectious Syphilis in Late Pregnancy. Sexually transmitted diseases. 2022 Oct 01;49(10):e107-e109