Protective Effect of Trimetazidine on Potassium Ion Homeostasis in Myocardial Tissue in Mice with Heart Failure.

Kaijing Yang, Yitao Xue, Miao Yu, Huachen Jiao, Yan Li, Xijin Wei, Wenwen Liu, Yang Sun, Nannan Chen, Linlin Song, Ting Yu, Kaiming Chen, Dadong Guo

BioMed research international 2022

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The occurrence of heart failure (HF) is closely correlated with the disturbance of mitochondrial energy metabolism, and trimetazidine (TMZ) has been regarded as an effective agent in treating HF. Intracellular potassium ion (K+) homeostasis, which is modulated by K+ channels and transporters, is crucial for maintaining normal myocardial function and can be disrupted by HF. This study is aimed at exploring the protective effect of TMZ on K+ homeostasis within myocardial tissue in mice with HF. We observed the pathological changes of myocardial tissue under microscopes and further measured the content of adenosine triphosphate (ATP), the activity of Na+-K+ ATPase, and the expression of ATP1α1 at the mRNA and protein levels. Moreover, we also analyzed the changes in K+ flux across the myocardial tissue in mice. As a result, we found that there was a large amount of myocardial fiber lysis and fracture in HF myocardial tissue. Meanwhile, the potassium flux of mice with HF was reduced, and the expression of ATP1α1, the activity of Na+-K+ ATPase, and the supply and delivery of ATP were also decreased. In contrast, TMZ can effectively treat HF by restoring K+ homeostasis in the local microenvironment of myocardial tissues. Copyright © 2022 Kaijing Yang et al.

Citation

Kaijing Yang, Yitao Xue, Miao Yu, Huachen Jiao, Yan Li, Xijin Wei, Wenwen Liu, Yang Sun, Nannan Chen, Linlin Song, Ting Yu, Kaiming Chen, Dadong Guo. Protective Effect of Trimetazidine on Potassium Ion Homeostasis in Myocardial Tissue in Mice with Heart Failure. BioMed research international. 2022;2022:2387860