Safety assessment of Streptococcus salivarius M18 a probiotic for oral health.

J D F Hale, R Jain, P A Wescombe, J P Burton, R R Simon, J R Tagg

Beneficial microbes 2022 Feb 28

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The development of probiotics targeting non-intestinal body sites continues to generate interest amongst researchers, biotech companies and consumers alike. A key consideration for any bacterial strain to be developed into a probiotic is a robust assessment of its safety profile. Streptococcus salivarius strain M18 was originally isolated from a healthy adult and evaluated for its probiotic capabilities targeted to dental and oral health applications. This publication presents the safety characterisation of strain M18. Application of a diverse range of techniques showed that strain M18 can be specifically distinguished from other S. salivarius using a variety of molecular and phenotypic methodologies and that it lacks any relevant antibiotic resistance or virulence determinants. Direct comparison of the strain M18 safety profile with that of the prototype S. salivarius probiotic, S. salivarius strain K12, supports the proposition that strain M18 is indeed safe for probiotic application in humans.

Citation

J D F Hale, R Jain, P A Wescombe, J P Burton, R R Simon, J R Tagg. Safety assessment of Streptococcus salivarius M18 a probiotic for oral health. Beneficial microbes. 2022 Feb 28;13(1):47-60