Successful treatment of vulvovaginal lichen planus with tildrakizumab: A case series of 24 patients.

Ashod Kherlopian, Gayle Fischer

The Australasian journal of dermatology 2022 May

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Vulvovaginal lichen planus (VLP) is a chronic inflammatory dermatosis affecting the genital skin and mucosa that can have a profound negative impact on patient quality of life. Up to 43% of women with VLP require systemic immunosuppression to achieve disease remission, and some individuals prove to be highly treatment resistant. We present a case series of 24 women with severe VLP who successfully achieved remission using off-label treatment with the interleukin-23 (IL-23) monoclonal antibody blocker tildrakizumab, and highlight tildrakizumab as a treatment for women with recalcitrant VLP who have failed more conservative treatments. © 2022 Australasian College of Dermatologists.

Citation

Ashod Kherlopian, Gayle Fischer. Successful treatment of vulvovaginal lichen planus with tildrakizumab: A case series of 24 patients. The Australasian journal of dermatology. 2022 May;63(2):251-255