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The capture of circulating tumor cells (CTCs) by nanostructured substrate surface is a useful method for early diagnosis of cancer. At present, most methods used to improve the cell capture efficiency are based on changing substrate surface properties. However, there are still some gaps between these methods and practical applications. Here, a method is presented for improving cell capture efficiency from a different perspective, that is, changing the properties of the cells. Concretely, the mechanical properties of the cell membrane are changed by adding Cytochalasin D to soften the cell membrane. Furthermore, a corresponding theoretical model is proposed to explain the experimental results. It is found that cell softening can reduce the resistance of cell adhesion, which makes the adhesion ability stronger. The high-efficiency capture of cells by softening the cell membrane provides a potential method to improve the detection performance of CTCs. © 2022 Wiley-VCH GmbH.


Ruiqi Ming, Ye Jiang, Jiaqi Fan, Chunchun An, Jinqi Li, Tongsheng Chen, Xinlei Li. High-Efficiency Capture of Cells by Softening Cell Membrane. Small (Weinheim an der Bergstrasse, Germany). 2022 Apr;18(13):e2106547

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PMID: 35112794

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