Correlation Engine 2.0
Clear Search sequence regions

  • anti hiv drugs (1)
  • main (1)
  • nucleosides (6)
  • oxygen (1)
  • sugar (2)
  • Sizes of these terms reflect their relevance to your search.

    Nucleoside analogues are at the forefront of antiviral therapy for last decades. To circumvent some of their limitations, based on their metabolism, and in order to improve their anti-viral potency and selectivity, several families of nucleoside analogues have been described through structural modifications at the sugar and heterocycles. The replacement of the oxygen of the nucleoside by a methylene has led to the family of carbocyclic (or cyclopentane) nucleoside analogues. Various potent anti-HIV and anti-HBV drugs belong to this family. Main syntheses of carbocyclic analogues of nucleosides used Diels-Alder reactions (in racemic or asymmetric series), but also started from carbohydrates (ribose, glucose), as a source of optically active compounds, which then had to be transformed into carbacycles under various conditions. The growing interest in carbocyclic nucleosides has led several groups, including ours, to develop new analogues and to explore novel routes. This article will review some of the recent chemistry developed on selected five-membered ring carbocyclic nucleosides. © 2022 The Chemical Society of Japan & Wiley-VCH GmbH.


    Andrea C Ojeda-Porras, Vincent Roy, Luigi A Agrofoglio. Chemical Approaches to Carbocyclic Nucleosides. Chemical record (New York, N.Y.). 2022 May;22(5):e202100307

    Expand section icon Mesh Tags

    Expand section icon Substances

    PMID: 35119191

    View Full Text