Research Progress on the Mechanism of Tubulin in Megakaryopoiesis and Regulation of Platelet Count--Review].

Si-Ying Niu, Li-Jun Xia, Miao Jiang

Zhongguo shi yan xue ye xue za zhi 2022 Feb

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Tubulin affects platelets count through the control of mitosis and the formation of pro-platelets during the maturation of megakaryoblast to platelets. Tubulin is involved in maintaining the integrity of platelet skeleton, and also participates in the change of platelet morphology during platelet activation. Some new anti-tumor drugs targeting cell mitosis are trying to reduce the effect on tubulin in order to reduce the side effect of drugs on platelet formation. In some patients with thrombocytopenia, the variation and polymorphism of the tubulin gene affect the structure of microtubule multimers, which leads to the decrease of platelet formation. This review summarized the latest progresses of tubulin in the regulation of megakaryopoiesis and thrombopoiesis.

Citation

Si-Ying Niu, Li-Jun Xia, Miao Jiang. Research Progress on the Mechanism of Tubulin in Megakaryopoiesis and Regulation of Platelet Count--Review]. Zhongguo shi yan xue ye xue za zhi. 2022 Feb;30(1):323-326