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This is the first phytochemical investigation of Schisandra tomentella A. C. Smith. 11 lignans and 8 sesquiterpenoids, were isolated from the stems of S. tomentella, including two undescribed lignans, tomentaschinins A-B (1-2), and two new sesquiterpenoids, tomentaschinnes A-B (3-4). Their structures were elucidated based on the interpretation of their spectroscopic data. Cytotoxicity and MDR reversal effect of these compounds were screened on multidrug resistance cancer cell line MCF-7/ADR, and results showed gomisin M2 (7) could promote the efficacy of adriamycin against MCF-7/ADR. Copyright © 2022 Elsevier B.V. All rights reserved.


Cai-Meng Wu, Wang Chu, Yi-Li Chen, Dong-E Liang, Fei-Jun Qiu, Zha-Jun Zhan, Lie-Feng Ma. Lignans and sesquiterpenes from Schisandra tomentella A. C. Smith. Fitoterapia. 2022 Apr;158:105142

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PMID: 35124161

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