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    The use of antibiotics can, in rare cases, induce neuromuscular blockade (NMB), resulting in paralytic symptoms. Although such antibiotic-induced NMB has been described in the anaesthesiology and infectious disease literature, it is an unfamiliar clinical entity in the fields of neurosurgery and spinal surgery. Herein, we report a case of periodic quadriplegia due to NMB induced by perioperative prophylactic antibiotic of cefazolin, resulting in highly confusing paralytic symptoms during the acute postoperative phase of cervical laminoplasty, together with a review of the relevant literature. © 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature.


    Shinya Ueyama, Sachio Hayama, Masahiro Mizutani, Yoshiharu Nakaya, Yoshitada Usami, Takashi Fujishiro, Masashi Neo. Periodic quadriplegia during the acute postoperative phase of cervical laminoplasty: a case report and literature review. Acta neurochirurgica. 2022 May;164(5):1229-1232

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    PMID: 35124746

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