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    Stiff-person syndrome (SPS) is a rare, autoimmune, neurological disorder that often occurs concurrently with other autoimmune disorders, such as type 1 diabetes mellitus, pernicious anaemia, vitiligo and Hashimoto's thyroiditis. It also can manifest as a paraneoplastic syndrome. Although SPS classically presents with truncal and appendicular stiffness and lumbar hyperlordosis, it can present focally in a single limb (termed stiff-limb syndrome). Here, we describe a woman with stiff-limb syndrome who initially presented with concerns about right foot swelling and pain. She also was positive for anti-GAD65 (anti-GAD2) antibodies. With treatment, she regained the ability to drive and ambulate without a walker, and she had a noted reduction in stimulus-induced spasms. © BMJ Publishing Group Limited 2022. No commercial re-use. See rights and permissions. Published by BMJ.


    Bala Munipalli, Jaimin S Shah. Unusual presentation of stiff-person syndrome in a patient with type 1 diabetes mellitus. BMJ case reports. 2022 Feb 07;15(2)

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    PMID: 35131796

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