Ulcerating nodules on a background of lower leg lymphoedema.

Mia Steyn, Nastassia Nardini, Natalie Rachel Attard

Clinical and experimental dermatology 2022 Apr

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A patient presented with a 3-month history of a rapidly enlarging ulcerated tumour on his lower leg, occurring on a background of chronic idiopathic lymphoedema of approximately 10 years' duration. Histology revealed extensive infiltration of the dermis by a vascular tumour with pleomorphic and hyperchromatic endothelial cells, which stained positive for vascular markers CD31, CD34 and ERG. A diagnosis of lymphoedema-associated angiosarcoma was reached and our patient was treated with isolated limb perfusion with high-dose melphalan and tumour necrosis factor-alfa. © 2022 British Association of Dermatologists.

Citation

Mia Steyn, Nastassia Nardini, Natalie Rachel Attard. Ulcerating nodules on a background of lower leg lymphoedema. Clinical and experimental dermatology. 2022 Apr;47(4):799-801