Clopidogrel-induced Eosinophilia with Hypercalcemia.

Kazuhiro Yamada, Kazuhisa Asai, Misaki Yanagimoto, Risa Sone, Satsuki Inazu, Ryo Mizutani, Hideaki Kadotani, Tetsuya Watanabe, Yoshihiro Tochino, Tomoya Kawaguchi

Internal medicine (Tokyo, Japan) 2022 Feb 08

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There are few cases describing the association of eosinophilia with hypercalcemia, and drug-induced eosinophilia with hypercalcemia has not been reported. A 74-year-old man had been diagnosed with asthma 4 months earlier. He was admitted due to eosinophilia with hypercalcemia. Chest computed tomography showed a nodule in the left lung and mediastinal lymphadenopathy. By obtaining a detailed medical history, clopidogrel was suspected as the prime cause of eosinophilia. After the discontinuation of clopidogrel, the eosinophilia with hypercalcemia, lung nodule and mediastinal lymphadenopathy improved. Clopidogrel-induced eosinophilia can potentially cause hypercalcemia. Obtaining a detailed clinical history is important in diagnosing the cause of eosinophilia.

Citation

Kazuhiro Yamada, Kazuhisa Asai, Misaki Yanagimoto, Risa Sone, Satsuki Inazu, Ryo Mizutani, Hideaki Kadotani, Tetsuya Watanabe, Yoshihiro Tochino, Tomoya Kawaguchi. Clopidogrel-induced Eosinophilia with Hypercalcemia. Internal medicine (Tokyo, Japan). 2022 Feb 08;61(17):2681-2685