Gout: an overview of diagnostics and treatment].

Iris Rose Peeters, A Martijn H Oude Voshaar, Anusha Moses, Tim L T A Jansen, Marcel Flendrie, Noortje van Herwaarden, Matthijs Janssen

Nederlands tijdschrift voor geneeskunde 2022 Jan 24

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Gout is characterized by acute arthritis due to the deposition of urate crystals in joints in a state of hyperuricemia. Gout is a clinical diagnosis and can be confirmed with a joint aspiration to examine the synovial fluid with a polarized light microscopy. If a joint aspiration is not feasible or inconclusive, ultrasound or Dual Energy Computed Tomography (DECT) can be considered. Pharmacological treatment of gout consists of treating acute flares with anti-inflammatory drugs and, if indicated, of urate lowering therapies (ULT). (Inter)national rheumatology guidelines recommend the use of ULT indefinite by a treat-to-target approach, but there is discussion whether (certain) patients might also be treated by a treat-to-avoid-symptoms approach. Two large Dutch trials are comparing these strategies in gout patients. Most gout patients have cardiovascular and metabolic comorbidities and therefore an indication for cardiovascular risk assessment.

Citation

Iris Rose Peeters, A Martijn H Oude Voshaar, Anusha Moses, Tim L T A Jansen, Marcel Flendrie, Noortje van Herwaarden, Matthijs Janssen. Gout: an overview of diagnostics and treatment]. Nederlands tijdschrift voor geneeskunde. 2022 Jan 24;166