Anti-LW Confused with Anti-D: a Case Transfused RhD-positive RBCs and Literature Review.

Min Young Lee, Woo In Lee, So Young Kang, Myeong Hee Kim

Clinical laboratory 2022 Feb 01

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Anti-LW is rarely identified, and it is known to have little clinical importance. However, it is often difficult to differentiate anti-LW from anti-D. Here, we report a case where anti-LW was identified for pretransfusion testing in a patient suspected of having lymphoma. His blood group was O RhD-positive. Anti-D specificity, weak panreactivity and 2+ reactivity in auto control were shown as a result of antibody identification. The reactions became weaker with DTT-treated RBCs, which confirmed the specificity of an anti-LW. The patient received 8 units of O RhD-positive pRBC before discharge without any transfusion reaction. In conclusion, anti-LWs may show mimicking specificity of anti-D for antibody identification testing, but their clinical significance is completely different. Therefore, their prompt identification is important.

Citation

Min Young Lee, Woo In Lee, So Young Kang, Myeong Hee Kim. Anti-LW Confused with Anti-D: a Case Transfused RhD-positive RBCs and Literature Review. Clinical laboratory. 2022 Feb 01;68(2)