Tetrahydrobiopterin and Its Multiple Roles in Neuropsychological Disorders.

Midhun T, S Swathi Krishna, Samson K Wilson

Neurochemical research 2022 May

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Tetrahydrobiopterin (BH4) is a multifunctional co-factor of various enzymes and a substantial amount of studies have shown BH4 as a key regulator in the synthesis of neurotransmitters such as serotonin, nor-epinephrine as well as dopamine. The imbalance of BH4 may affect neurotransmitter production which can lead to many abnormalities in CNS. This article reviews the role of BH4 in neurodegenerative and neurodevelopmental disorders. We focus on the therapeutic potential of BH4 in various brain diseases that involves neurotransmitters and attempt to address how the modulation of BH4 may provide a novel strategy in various neuropsychological conditions. © 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

Citation

Midhun T, S Swathi Krishna, Samson K Wilson. Tetrahydrobiopterin and Its Multiple Roles in Neuropsychological Disorders. Neurochemical research. 2022 May;47(5):1202-1211