Efficient Photocatalytic Carbonyl Alkylative Amination Enabled by Titanium-Dioxide-Mediated Decarboxylation.

Mei Xu, Ying Hua, Xin Fu, Jie Liu

Chemistry (Weinheim an der Bergstrasse, Germany) 2022 Mar 10

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Herein, a heterogeneous carbonyl alkylative amination reaction that proceeds by photoredox catalysis has been developed. The use of nano titanium dioxide (TiO2 , 25 nm) as photocatalyst allows efficient synthesis of diverse amines in good to excellent yields. Mechanistic studies reveal a single-electron-transfer mechanism involving the photoexcitation of TiO2 to generate alkyl radicals from carboxylic acids decarboxylation. This protocol highlights the utility of using heterogeneous semiconductor photocatalysts to promote a practical and general synthesis of complex amines from readily available feedstocks. © 2022 Wiley-VCH GmbH.

Citation

Mei Xu, Ying Hua, Xin Fu, Jie Liu. Efficient Photocatalytic Carbonyl Alkylative Amination Enabled by Titanium-Dioxide-Mediated Decarboxylation. Chemistry (Weinheim an der Bergstrasse, Germany). 2022 Mar 10;28(15):e202104394