Regulation of Cell Polarity by Posttranslational Protein Palmitoylation.

Baoen Chen, Carla Guarino, Abdelhalim Azzi, Hannah Erb, Xu Wu

Methods in molecular biology (Clifton, N.J.) 2022

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Cell polarity is a common feature of many living cells, especially epithelial cells, and plays important roles in development, tissue homeostasis, and diseases. Therefore, the signaling pathways involved in establishing and maintaining cell polarity are tightly controlled. Protein S-palmitoylation has been recently recognized as an important posttranslational modification involved in cell polarity, via dynamic covalent attachment of fatty acyl groups to the cysteine residues of cell polarity proteins. Here, we describe the methods to study the function and regulation of S-palmitoylation of cell polarity proteins. © 2022. Springer Science+Business Media, LLC, part of Springer Nature.

Citation

Baoen Chen, Carla Guarino, Abdelhalim Azzi, Hannah Erb, Xu Wu. Regulation of Cell Polarity by Posttranslational Protein Palmitoylation. Methods in molecular biology (Clifton, N.J.). 2022;2438:107-121