How the size and shape of developing tissues is encoded in the genome has been a longstanding riddle for biologists. Constituent cells integrate several genetic and mechanical signals to decide whether to divide, die, change shape or position. We review here how morphogenetic cell behaviors contribute to leg formation from imaginal disc epithelia in the insect Drosophila melanogaster, as well as to direct embryonic limb outgrowths in the non-insect pancrustacean Parhyale hawaiensis. Considering the deep conservation of developmental programs for limb patterning among arthropods and other bilaterians, moving forward, it will be exciting to see how these genetic similarities reflect at the cellular and tissue mechanics level. Copyright © 2022 Elsevier Inc. All rights reserved.
Citation
John Rallis, Anastasios Pavlopoulos. Cellular basis of limb morphogenesis. Current opinion in insect science. 2022 Apr;50:100887
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PMID: 35150918
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