Biphasic squamoid alveolar renal cell carcinoma: Cytologic features of a rare entity.

Michael R McCarthy, Christin A Tiegs-Heiden, Charles D Sturgis, Amy A Swanson, Sounak Gupta, Judith Jebastin Thangaiah, Christopher P Hartley

Annals of diagnostic pathology 2022 Jun

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Biphasic squamoid alveolar renal cell carcinoma is a newly described rare morphologic variant of papillary renal cell carcinoma. Its characteristic histomorphology and immunophenotype have been well described in the literature. Namely, BSARCC is composed of a dual-cell population with nests of larger squamoid cells surrounded by a single layer of cuboidal cells in alveolar arrangements. Invariably, the squamoid component expresses cyclin D1. More recently, MET alterations have been identified within a subset of BSARCC, raising the possibility for targeted MET inhibitor therapy. To the best of our knowledge the cytomorphologic features of BSARCC have yet to be described. Herein we correlate the cytologic features (percutaneous image-guided fine needle aspiration) of BSARCC to its corresponding histomorphology and immunophenotype (core needle biopsy). Copyright © 2022 Elsevier Inc. All rights reserved.

Citation

Michael R McCarthy, Christin A Tiegs-Heiden, Charles D Sturgis, Amy A Swanson, Sounak Gupta, Judith Jebastin Thangaiah, Christopher P Hartley. Biphasic squamoid alveolar renal cell carcinoma: Cytologic features of a rare entity. Annals of diagnostic pathology. 2022 Jun;58:151906