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Amantadine was originally developed as an antiviral agent for influenza A. However, it also has off-label uses for Parkinson disease, multiple sclerosis, and in the management of extrapyramidal symptoms. The mechanism of action in these conditions has yet to be elucidated. Ocular side effects from systemic amantadine are rare but have been described in three previous reports of amantadine-associated corneal edema in the pediatric population. We present an additional case of amantadine-associated transient visual impairment in a patient, which was associated with significant regression and worsening of his underlying neurodevelopmental status. Published by Elsevier Inc.


Jonathan Chao, Steven Dunn, Lisa Bohra. Amantadine-induced bilateral corneal edema in a pediatric patient. Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus. 2022 Jun;26(3):150-152

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PMID: 35151873

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