Yi Zhao, Yaoyao Liu, Na Li, Murtala Muhammad, Siyu Gong, Jiansong Ju, Tongxuan Cai, Jialu Wang, Baohua Zhao, Dong Liu
Future microbiology 2022 MarAim: To investigate the function of broad-spectrum racemases in Aeromonas hydrophila (BsrA). Results: The A. hydrophila gene encoding BsrA (bsr) mutants (AHΔbsr) exhibited a significant decrease in growth, motility, extracellular protease production and biofilm formation compared with the wild-type. Furthermore, bsr gene knockout instigated cell wall damage compared with the wild-type strains. The survival rate and replication capability in the blood and organs of the AHΔbsr-infected mice were significantly decreased. The degree of tissue injury in the AHΔbsr-infected group was lower than that of the wild-type-infected group. Moreover, there was a significant decrease in the expression of 12 AHΔbsr virulence genes. Conclusion: The bsr gene is essential for the viability and virulence of A. hydrophila.
Yi Zhao, Yaoyao Liu, Na Li, Murtala Muhammad, Siyu Gong, Jiansong Ju, Tongxuan Cai, Jialu Wang, Baohua Zhao, Dong Liu. Significance of broad-spectrum racemases for the viability and pathogenicity of Aeromonas hydrophila. Future microbiology. 2022 Mar;17:251-265
PMID: 35152710
View Full Text