Human Chorionic Gonadotropin and Early Embryogenesis: Review.

Sophie Perrier d'Hauterive, Romann Close, Virginie Gridelet, Marie Mawet, Michelle Nisolle, Vincent Geenen

International journal of molecular sciences 2022 Jan 26

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Human chorionic gonadotropin (hCG) has four major isoforms: classical hCG, hyperglycosylated hCG, free β subunit, and sulphated hCG. Classical hCG is the first molecule synthesized by the embryo. Its RNA is transcribed as early as the eight-cell stage and the blastocyst produces the protein before its implantation. This review synthetizes everything currently known on this multi-effect hormone: hCG levels, angiogenetic activity, immunological actions, and effects on miscarriages and thyroid function.

Citation

Sophie Perrier d'Hauterive, Romann Close, Virginie Gridelet, Marie Mawet, Michelle Nisolle, Vincent Geenen. Human Chorionic Gonadotropin and Early Embryogenesis: Review. International journal of molecular sciences. 2022 Jan 26;23(3)