One-Pot Synthesis of Novel 2-Imino-5-Arylidine-Thiazolidine Analogues and Evaluation of Their Anti-Proliferative Activity against MCF7 Breast Cancer Cell Line.

Marian N Aziz, Arzoo Patel, Amany Iskander, Avisankar Chini, Delphine Gout, Subhrangsu S Mandal, Carl J Lovely

Molecules (Basel, Switzerland) 2022 Jan 27

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An efficient surface-mediated synthetic method to facilitate access to a novel class of thiazolidines is described. The rationale behind the design of the targeted thiazolidines was to prepare stable thiazolidine analogues and evaluate their anti-proliferative activity against a breast cancer cell line (MCF7). Most of the synthesized analogues exhibited increased potency ranging from 2-15-fold higher compared to the standard reference, cisplatin. The most active thiazolidines contain a halogenated or electron withdrawing group attached to the N-phenyl ring of exocyclic 2-imino group. However, combination of the two substituents did not enhance the activity. The anti-proliferative activity was measured in terms of IC50 values using an MTT assay.

Citation

Marian N Aziz, Arzoo Patel, Amany Iskander, Avisankar Chini, Delphine Gout, Subhrangsu S Mandal, Carl J Lovely. One-Pot Synthesis of Novel 2-Imino-5-Arylidine-Thiazolidine Analogues and Evaluation of Their Anti-Proliferative Activity against MCF7 Breast Cancer Cell Line. Molecules (Basel, Switzerland). 2022 Jan 27;27(3)