The ins and outs of the flavin mononucleotide cofactor of respiratory complex I.

Andrea Curtabbi, José Antonio Enríquez

IUBMB life 2022 Jul

filter terms:

The flavin mononucleotide (FMN) cofactor of respiratory complex I occupies a key position in the electron transport chain. Here, the electrons coming from NADH start the sequence of oxidoreduction reactions, which drives the generation of the proton-motive force necessary for ATP synthesis. The overall architecture and the general catalytic proprieties of the FMN site are mostly well established. However, several aspects regarding the complex I flavin cofactor are still unknown. For example, the flavin binding to the N-module, the NADH-oxidizing portion of complex I, lacks a molecular description. The dissociation of FMN from the enzyme is beginning to emerge as an important regulatory mechanism of complex I activity and ROS production. Finally, how mitochondria import and metabolize FMN is still uncertain. This review summarizes the current knowledge on complex I flavin cofactor and discusses the open questions for future research. © 2022 International Union of Biochemistry and Molecular Biology.

Citation

Andrea Curtabbi, José Antonio Enríquez. The ins and outs of the flavin mononucleotide cofactor of respiratory complex I. IUBMB life. 2022 Jul;74(7):629-644