Advances in the progress of monoclonal antibodies for rabies.

Linlin Fan, Li Zhang, Jingxin Li, Fengcai Zhu

Human vaccines & immunotherapeutics 2022 Dec 31

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Rabies is a highly fatal zoonotic disease caused by the rabies virus invading the central nervous system. When suspected of exposure to the rabies virus, post-exposure prophylaxis should be administered as soon as possible. Monoclonal antibodies (mAbs) neutralizing the rabies virus could be better in human rabies post-exposure prophylaxis than equine or human rabies immune globulin in terms of supply, cost, and efficacy. This article reviews anti-rabies mAbs produced by multiple techniques, and the results of clinical trials for anti-rabies mAbs cocktails recognizing non-overlapping epitopes are also discussed.

Citation

Linlin Fan, Li Zhang, Jingxin Li, Fengcai Zhu. Advances in the progress of monoclonal antibodies for rabies. Human vaccines & immunotherapeutics. 2022 Dec 31;18(1):2026713